Autoantibodies in heart failure
Investigating the role of autoantibodies in heart failure.
Research
Understanding how metabolism and mitochondrial function shape heart disease.
Current research
Engineering the mitochondrial genome
Part of a project within the £66M Precision Mitochondria programme, developing tools to engineer the mitochondrial genome.
Doctoral research
Targeting Elevated Intracellular Sodium and Metabolic Reprogramming in Heart Failure
King’s College London
My PhD investigated how elevated intracellular sodium alters cardiac metabolism, and whether lowering sodium could help reverse metabolic reprogramming in heart failure. Using isolated hearts, cell models and optogenetic tools, I explored the relationship between sodium homeostasis, mitochondrial function and cardiac energetics.
Advisors
- Prof Michael ShattockCellular Cardiology · King’s College London
- Dr Thomas EykynBiomedical Engineering & Imaging · King’s College London
Collaborations
- Prof Michael MurphyMRC Mitochondrial Biology Unit · University of Cambridge
- Prof Tobias BruegmannOptogenetics · University of Göttingen
- Prof Thomas KampourakisMolecular biophysics · University of Kentucky
Previous projects
Cardiometabolic research
Imperial College London
Gut microbiome metabolites
Investigating the role of gut microbiome metabolites in cardiometabolic disease.
Selected publications
Research outputs
- Beyond glucose: metabolic substrate provision enhances cardiac energetics, function and stability ex vivo: a simple recipe for healthier hearts?
- Diltiazem N-oxide, a novel ischaemia-activated prodrug, prevents ischaemia-induced ventricular fibrillation without off-target adverse effects
- Disrupting Na+ ion homeostasis and Na+/K+ ATPase activity in breast cancer cells directly modulates glycolysis in vitro and in vivo
- Elevated Na is a dynamic and reversible modulator of mitochondrial metabolism in the heart
- Discovery of a novel cardiac-specific myosin modulator using artificial intelligence-based virtual screening